Ethanol → HCID 11819299, 화합물

HRID 1173765노트

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HRID 1173765 반응식
Cl[CH:2]([CH:8]([OH:12])[CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C(O)C.[O-]CC.[Na+].C(O)C>CCCCCC>[CH2:9]([C@@H:8]1[O:12][C@H:2]1[C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH2:10][CH3:11]

참가 물질

5

반응물 3

HCID 702EthanolHCID 22298443HCID 22298443, 화합물HCID 23706232Ethanol sodium ethoxide

생성물 1

HCID 11819299HCID 11819299, 화합물수율 87%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Ethyl 2-chloro-3-hydroxyhexanoate synthesized in Example 9 (0.8 g, 4 mmol), ethanol (3 ml) and 20% sodium ethoxide/ethanol solution (1.52 g, 1.1 equivalents) were mixed, and the mixture was stirred at room temperature for 30 minutes. Hexane (10 ml) was added, and the mixture was washed with water (10 ml×twice). After the mixture was dried with anhydrous magnesium sulfate, the inorganic salt was separated by filtration. The filtrate was concentrated under reduced pressure. The title compound was obtained as a colorless oil (0.9 g, yield: 87%, (2R,3S) was the main ingredient).

후처리

  1. washthe mixture was washed with water (10 ml×twice)
  2. dry with materialAfter the mixture was dried with anhydrous magnesium sulfate
  3. customthe inorganic salt was separated by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6471f42b52b3415e8e1c15bc4123de96
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834190B2

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