Formic Acid → HCID 22298443, 화합물

HRID 1173778노트

반응식

HRID 1173778 반응식
[Cl:1][CH:2]([C:8](=[O:12])[CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C(N(CC)CC)C.C(O)=O>ClC1C=CC=CC=1>[Cl:1][CH:2]([CH:8]([OH:12])[CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 8471TriethylamineHCID 11424094Ethyl 2-chloro-3-oxohexanoate

생성물 1

HCID 22298443HCID 22298443, 화합물

시약·촉매·용매 1

HCID 7964Chlorobenzene용매

실험 절차

Ethyl 2-chloro-3-oxohexanoate (194 mg), chlorobenzene (3 ml), RuCl[(S,S)-TsDPEN](p-cymene) complex (1 mol %) and triethylamine (5 equivalents) were mixed, and formic acid (3 equivalents) was gradually added thereto. The reaction was carried out at 40° C. for 3 hours. The reaction mixture was analyzed. As a result, the conversion ratio was 100%, and the isomer ratio of (2S,3R):(2S,3S):(2R,3R):(2R,3S) is 63.7:24.9:4.1:7.3.

출처 및 근거

ORD 기록
ord-9917489f69bb4effad58083d1a3b3065
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834190B2

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