1,4-Dioxane hydrochloride → n,n-Dipropylpropane-1,3-diamine

The compound (2.67 g) obtained in Example 22-2 was dissolved in anhydrous methanol (2.0 ml) and then added with a 4 mol/l hydrogen chloride/dioxane solution (20.0 ml), followed by stirring at room temperature for 1.5 hours. After completion of the reaction, the solvent was distilled off. Then, the residue was added with a 1 mol/l sodium hydroxide aqueous solution and extracted with dichloromethane. The extract was washed with distilled water and saturated saline solution, and then the organic layer was dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off, thereby obtaining the subject compound (726 mg) as a pale-yellow liquid.

1. customAfter completion of the reaction
2. distillationthe solvent was distilled off
3. additionThen, the residue was added with a 1 mol/l sodium hydroxide aqueous solution
4. extractionextracted with dichloromethane
5. washThe extract was washed with distilled water and saturated saline solution
6. dry with materialthe organic layer was dried with anhydrous sodium sulfate
7. distillationSubsequently, the solvent was distilled off

ORD 기록

ord-9effc3af86fb4dc4b0b5ace4280fee08

출처 데이터셋

uspto-grants-2010_11

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07833991B2