Pyridine → rac-(2'S,3'S,4'S)-6-chloro-2'-(3-chloro-2-fluoro-phenyl)-4'-(2,2-dimethyl-propyl)-1H-spiro[indole-3,3'-pyrrolidin]-2-one

HRID 117392

반응식

HRID 117392 반응식
[Cl:20][c:21]1[c:22]([F:29])[c:23]([CH:24]=[O:25])[cH:26][cH:27][cH:28]1.[NH2:1][CH2:2][CH:3]([CH2:4][C:5]([CH3:6])([CH3:7])[CH3:8])[CH:9]1[C:10](=[O:19])[NH:11][c:12]2[cH:13][c:14]([Cl:18])[cH:15][cH:16][c:17]21.[cH:30]1[cH:31][cH:32][n:33][cH:34][cH:35]1>>[NH:1]1[CH2:2][CH:3]([CH2:4][C:5]([CH3:6])([CH3:7])[CH3:8])[C:9]2([C:10](=[O:19])[NH:11][c:12]3[cH:13][c:14]([Cl:18])[cH:15][cH:16][c:17]32)[CH:24]1[c:23]1[c:22]([F:29])[c:21]([Cl:20])[cH:28][cH:27][cH:26]1

참가 물질

4

반응물 3

HCID 1049PyridineHCID 7363353-Chloro-2-fluorobenzaldehydeHCID 58399003Racemic 3-(1-aminomethyl-3,3-dimethyl-butyl)-6-chloro-1,3-dihydro-indol-2-one

생성물 1

HCID 67336394rac-(2'S,3'S,4'S)-6-chloro-2'-(3-chloro-2-fluoro-phenyl)-4'-(2,2-dimethyl-propyl)-1H-spiro[indole-3,3'-pyrrolidin]-2-one

출처 및 근거

ORD 기록
ord-39043fef65d74f0f9c8a831008fd0b25
출처 데이터셋
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

연결된 노트

불러오는 중…