Methanol → 4-dipropylaminomethylbenzyl Alcohol

HRID 1173931

반응식

HRID 1173931 반응식
[CH2:1]([N:4]([CH2:8][C:9]1[CH:18]=[CH:17][C:12]([C:13](OC)=[O:14])=[CH:11][CH:10]=1)[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3].[H-].[Al+3].[Li+].[H-].[H-].[H-].CO.C(C(C(C([O-])=O)O)O)([O-])=O.[Na+].[K+]>C1COCC1>[CH2:1]([N:4]([CH2:8][C:9]1[CH:18]=[CH:17][C:12]([CH2:13][OH:14])=[CH:11][CH:10]=1)[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3]

참가 물질

6

반응물 4

HCID 887MethanolHCID 9855836Potassium sodium tartarateHCID 21226445Aluminium lithium hydrideHCID 23079192Methyl 4-dipropylaminomethylbenzoate

생성물 1

HCID 669412924-dipropylaminomethylbenzyl Alcohol수율 92%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The compound (1.47 g) obtained in Example 80-1 was dissolved in anhydrous THF (50 ml). Then, the solution was added with lithium aluminum hydride (671 mg) in an ice bath, followed by stirring at room temperature for 1 hour. After completion of the reaction, the solution was added with methanol and then added with an aqueous potassium sodium tartrate solution, followed by stirring. The solution was extracted with chloroform and the extract was then washed with saturated saline solution. The organic layer was dried with anhydrous sodium sulfate and the solvent was then distilled off, thereby obtaining the subject compound (1.20 g) as a colorless liquid.

후처리

  1. customAfter completion of the reaction
  2. stirringby stirring
  3. extractionThe solution was extracted with chloroform
  4. washthe extract was then washed with saturated saline solution
  5. dry with materialThe organic layer was dried with anhydrous sodium sulfate
  6. distillationthe solvent was then distilled off

출처 및 근거

ORD 기록
ord-002b64d05b774fdf8f1a1753e5ee77ac
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07833991B2

연결된 노트

불러오는 중…