6-(Bromomethyl)-2-methylquinoline → 2-(2-Methylquinolin-6-ylmethyl)-isoindole-1,3-dione

HRID 1173977

반응식

HRID 1173977 반응식
Br[CH2:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([CH3:13])[CH:7]=[CH:6]2.[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.[K]>CN(C=O)C>[CH3:13][C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([CH2:2][N:18]3[C:14](=[O:24])[C:15]4[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=4)[C:17]3=[O:19])[CH:4]=2)[N:9]=1

참가 물질

4

반응물 2

HCID 27954806-(Bromomethyl)-2-methylquinolineHCID 24194345Phthalimide potassium salt

생성물 1

HCID 230791882-(2-Methylquinolin-6-ylmethyl)-isoindole-1,3-dione수율 99.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The compound (421.7 mg) obtained in Example 119-1 was dissolved in anhydrous DMF (12.6 ml) and added with potassium phthalimide (663.1 mg), followed by stirring at room temperature for 2 hours. After the reaction, the solvent was distilled off and the residue was then added with water. The mixture was extracted with chloroform and the extract was dried with magnesium sulfate. The solvent was distilled off and the residue was then purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (536.0 mg) as a white solid.

후처리

  1. customAfter the reaction
  2. distillationthe solvent was distilled off
  3. additionthe residue was then added with water
  4. extractionThe mixture was extracted with chloroform
  5. dry with materialthe extract was dried with magnesium sulfate
  6. distillationThe solvent was distilled off
  7. customthe residue was then purified through silica gel column chromatography (chloroform/ethyl acetate)

출처 및 근거

ORD 기록
ord-e0051928026e48a7ae95d4550f6edc0f
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07833991B2

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