2-Phthalimidomethyl-6-(3-dipropylaminopropyl)naphthalene → 2-Aminomethyl-6-(3-dipropylaminopropyl)naphthalene

HRID 1173993노트

반응식

HRID 1173993 반응식
C1(=O)[N:5]([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([CH2:17][CH2:18][CH2:19][N:20]([CH2:24][CH2:25][CH3:26])[CH2:21][CH2:22][CH3:23])[CH:13]=3)[CH:8]=2)C(=O)C2=CC=CC=C12>CN.CO>[NH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:17][CH2:18][CH2:19][N:20]([CH2:24][CH2:25][CH3:26])[CH2:21][CH2:22][CH3:23])[CH:13]=2)[CH:8]=1

참가 물질

3

반응물 1

HCID 230792442-Phthalimidomethyl-6-(3-dipropylaminopropyl)naphthalene

생성물 1

HCID 230792162-Aminomethyl-6-(3-dipropylaminopropyl)naphthalene수율 92.6%

시약·촉매·용매 1

HCID 57454252Monomethylamine methanol용매

실험 절차

The compound (439 mg) obtained in Example 121-10 was dissolved in a 40% methylamine/methanol solution (45 ml) and stirred at room temperature for 3 days. After completion of the reaction, the solvent was distilled off. Then, a 1 mol/l sodium hydroxide aqueous solution was added to the residue, and the whole was stirred. The solution was extracted with chloroform and the extract was washed with saturated saline solution. After that, the organic layer was dried with anhydrous sodium sulfate. Then, the solvent was distilled off, thereby obtaining the subject compound (283 mg) as a colorless oily substance.

후처리

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off
  3. additionThen, a 1 mol/l sodium hydroxide aqueous solution was added to the residue
  4. stirringthe whole was stirred
  5. extractionThe solution was extracted with chloroform
  6. washthe extract was washed with saturated saline solution
  7. dry with materialAfter that, the organic layer was dried with anhydrous sodium sulfate
  8. distillationThen, the solvent was distilled off

출처 및 근거

ORD 기록
ord-6c4e3cfa13304a7eb2326acbc48a4991
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07833991B2

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