1-Methylpyrrolidine → 1-(Methoxymethyl)-1-methylpyrrolidin-1-ium bromide
반응식
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:7][O:8][CH2:9][Br:10]>CC(C)=O.O>[Br-:10].[CH3:7][O:8][CH2:9][N+:2]1([CH3:1])[CH2:6][CH2:5][CH2:4][CH2:3]1참가 물질
5
반응 조건
- 온도
- 15 °C
실험 절차
A 17.0 g quantity of N-methylpyrrolidine was dissolved in 160 g of dehydrated acetone (up to 0.1% in water content), followed by nitrogen replacement. To the solution was added dropwise 24.6 g of bromomethyl methyl ether (reagent, product of Tokyo Kasei Co., Ltd.) at 5° C. over a period of 1.5 hours. The mixture was stirred at 5 to not higher than 15° C. for 4 hours to terminate the reaction. The reaction mixture was filtered, and the resulting solids were washed with 160 g of acetone, and dried in a vacuum, affording 30.9 g of the desired product (white solid).
후처리
- customto terminate
- customthe reaction
- filtrationThe reaction mixture was filtered
- washthe resulting solids were washed with 160 g of acetone
- customdried in a vacuum
출처 및 근거
- ORD 기록
- ord-d84364220cfa4c0ea714dd4573354c86
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07834197B2
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