Sulfuric acid magnesium salt (1:1) → Ethyl 2-(methoxymethyl)-1,3-thiazole-4-carboxylate
반응식
[CH3:1][O:2][CH2:3][C:4](=[S:6])[NH2:5].Br[CH2:8][C:9](=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11].S([O-])([O-])(=O)=O.[Mg+2]>CC(C)=O>[CH3:1][O:2][CH2:3][C:4]1[S:6][CH:8]=[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:5]=1참가 물질
5
반응 조건
- 온도
- 25 °C
실험 절차
A solution containing the product from Example 6B (7 g, 66.6 mmol) in acetone (270 mL) was treated with ethyl bromopyruvate (8.4 mL, 66.6 mmol) and magnesium sulfate (7.9 g, 66.6 mmol), heated at reflux for 16 hours, cooled to 25° C., filtered and concentrated. The residue was chromatographed on silica gel eluting with chloroform to give the title compound (7.6 g, 57% yield).
후처리
- temperatureheated
- temperatureat reflux for 16 hours
- filtrationfiltered
- concentrationconcentrated
- customThe residue was chromatographed on silica gel eluting with chloroform
출처 및 근거
- ORD 기록
- ord-c309c551cafd42dfad164da8f90a272b
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07834043B2
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