홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Trifluoroacetic acid → (2S,3S)-2-(2,4-dioxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)-3-methylpentanoic Acid

HRID 1174212
노트
인쇄 미리보기

반응식

HRID 1174212 반응식
[O:1]=[C:2]1[N:6]([CH2:7][C:8]2[N:9]=[C:10]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)[S:11][CH:12]=2)[C:5](=[O:19])[CH2:4][N:3]1[C@@H:20]([C@@H:28]([CH3:31])[CH2:29][CH3:30])[C:21]([O:23]C(C)(C)C)=[O:22].FC(F)(F)C(O)=O>ClCCl>[O:1]=[C:2]1[N:6]([CH2:7][C:8]2[N:9]=[C:10]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)[S:11][CH:12]=2)[C:5](=[O:19])[CH2:4][N:3]1[C@@H:20]([C@@H:28]([CH3:31])[CH2:29][CH3:30])[C:21]([OH:23])=[O:22]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acid2회HCID 67406421tert-butyl(2S,3S)-2-(2,4-dioxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)-3-methylpentanoate

생성물 1

HCID 67408846(2S,3S)-2-(2,4-dioxo-3-{[2-(3-pyridinyl)-1,3-thiazol-4-yl]methyl}-1-imidazolidinyl)-3-methylpentanoic Acid수율 153.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

A solution containing the product from Example 57B (0.090 g, 0.220 mmol) in dichloromethane (2 mL) was treated with trifluoracetic acid (2 mL), stirred at 25° C. for 16 hours, and concentrated. The residue was purified by reversed phase chromatography on a C18 column eluting with 5-100% acetonitrile in water (0.1% TFA) to give the title compound (0.131 g, 90% yield) as the trifluoroacetic acid salt.

후처리

  1. concentrationconcentrated
  2. customThe residue was purified by reversed phase chromatography on a C18 column
  3. washeluting with 5-100% acetonitrile in water (0.1% TFA)

출처 및 근거

ORD 기록
ord-e75fd3be7cbc4d5293e3c3f7b2d277ae
출처 데이터셋
uspto-grants-2010_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07834043B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트