Pivalaldehyde → 2,2-Dimethyl-5-hexen-3-ol

HRID 1174314노트

반응식

HRID 1174314 반응식
[CH3:1][C:2]([CH3:6])([CH3:5])[CH:3]=[O:4].[CH2:7]([Mg]Br)[CH:8]=[CH2:9]>C(OCC)C>[CH3:1][C:2]([CH3:6])([CH:3]([OH:4])[CH2:9][CH:8]=[CH2:7])[CH3:5]

참가 물질

4

반응물 2

HCID 12417PivalaldehydeHCID 178455850HCID 178455850, 화합물

생성물 1

HCID 1405562,2-Dimethyl-5-hexen-3-ol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
0 °C

실험 절차

A solution of trimethylacetaldehyde (10.2 mL, 90.9 mmol) in diethyl ether (200 mL) at 0° C. was treated with allylmagnesium bromide (100 mL, 1 M in ether), stirred at 0° C. for 1 hour, quenched with saturated ammonium chloride and extracted with diethyl ether. The organic phase was washed with brine and dried over Na2SO4, filtered and concentrated to give the title compound (11.6 g).

후처리

  1. customquenched with saturated ammonium chloride
  2. extractionextracted with diethyl ether
  3. washThe organic phase was washed with brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b43ebccd1ac24905b74a717053e46356
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834043B2

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