Triacetoxyperiodinane → 3-Methyl-2-nitrobenzaldehyde

HRID 1174352노트

반응식

HRID 1174352 반응식
[CH3:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][OH:6].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(#N)C>[CH3:1][C:2]1[C:3]([N+:10]([O-:12])=[O:11])=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6]

참가 물질

4

반응물 2

HCID 159087TriacetoxyperiodinaneHCID 5619893-Methyl-2-nitrobenzenemethanol

생성물 1

HCID 135735673-Methyl-2-nitrobenzaldehyde수율 98%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 3-methyl-2-nitrobenzyl alcohol (0.4 g, 2.4 mmol) in acetonitrile (8 mL) was treated with Dess-Martin reagent (1.11 g, 2.63 mmol) at 25° C. for 16 h. The mixture was quenched with sodium bicarbonate/sodium thiosulfate (1:1, 15 mL), and the mixture was extracted with dichloromethane, the organic layer separated, washed with brine, dried over sodium sulfate, filtered, and the solvents were evaporated to give the crude title compound (0.387 g, 98%).

후처리

  1. customThe mixture was quenched with sodium bicarbonate/sodium thiosulfate (1:1, 15 mL)
  2. extractionthe mixture was extracted with dichloromethane
  3. customthe organic layer separated
  4. washwashed with brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. customthe solvents were evaporated

출처 및 근거

ORD 기록
ord-67b24b1500684ef7803136e998954f78
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834043B2

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