Acetone → Propanoic acid, 2-methyl-3-(methylsulfonyl)-, (S)-

HRID 1174369노트

반응식

HRID 1174369 반응식
[CH3:1][C@H:2]([CH2:6]SC)[C:3]([OH:5])=[O:4].O[O:10][S:11]([O-:13])=O.[K+].[CH3:15]C(C)=O>O>[CH3:1][C@H:2]([CH2:6][S:11]([CH3:15])(=[O:13])=[O:10])[C:3]([OH:5])=[O:4]

참가 물질

5

반응물 3

HCID 180AcetoneHCID 23707502Potassium hydroxy sulfiteHCID 51669008HCID 51669008, 화합물

생성물 1

HCID 15814191Propanoic acid, 2-methyl-3-(methylsulfonyl)-, (S)-수율 45%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
25 °C

실험 절차

A solution of Example 149A (0.085 g, 0.63 mmol) in acetone (1.2 mL) and water (0.25 mL) at 0° C. was treated with oxone (1.17 g, 1.9 mmol) and the mixture was stirred at 25° C. for 3 h. The mixture was filtered, rinsed with acetone, and the solvents were evaporated. The residue was dissolved in ethyl acetate, dried over MgSO4, filtered and the solvents were evaporated to give the crude title compound (47 mg, 45%).

후처리

  1. filtrationThe mixture was filtered
  2. washrinsed with acetone
  3. customthe solvents were evaporated
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. customthe solvents were evaporated

출처 및 근거

ORD 기록
ord-01c3497e07fd4911b953457185c6a005
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834043B2

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