Trifluoroacetic acid → (αS)-α-(1,1-Dimethylethyl)-2-oxo-1-imidazolidineacetic acid

HRID 1174384노트

반응식

HRID 1174384 반응식
[CH3:1][C:2]([CH3:18])([CH3:17])[C@H:3]([N:11]1[CH2:15][CH2:14][NH:13][C:12]1=[O:16])[C:4]([O:6]C(C)(C)C)=[O:5].FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]([CH3:18])([CH3:17])[C@H:3]([N:11]1[CH2:15][CH2:14][NH:13][C:12]1=[O:16])[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67406576HCID 67406576, 화합물

생성물 1

HCID 20682363(αS)-α-(1,1-Dimethylethyl)-2-oxo-1-imidazolidineacetic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution containing the product from Example 160A (0.050 g, 0.195 mmol) in dichloromethane (1.0 mL) was added trifluoracetic acid (1.0 mL), and the mixture was stirred at room temperature for 2 hours. The solvent was evaporated and the residue was triturated with ether to give a white solid, which was collected by filtration and used without further purification.

후처리

  1. customThe solvent was evaporated
  2. customthe residue was triturated with ether
  3. customto give a white solid, which
  4. filtrationwas collected by filtration
  5. customused without further purification

출처 및 근거

ORD 기록
ord-edcb6dfbfb7d43bca5e15fe488d6c8d3
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834043B2

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