Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → N-Methyl-6-nitrobenzo[D]thiazol-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | 2-Chloro-6-nitrobenzothiazole | HCID 75476 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-Methyl-6-nitrobenzo[D]thiazol-2-amine | HCID 638568 | 88% |
반응 단계
Place 2-chloro-6-nitro-benzothiazole (5.82 g, 27.1 mmol) in THF (130 mL). Add 40% methylamine in water (7 mL) and stir until the product precipitates out. Concentrate in vacuo and then triturate with methanol. Filter off the product and wash with methanol, Dry thoroughly to yield 4.99 g (88%) of the title compound: mass spectrum (ion-spray): (m/z)=210.0 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07838543B2 |
| 출처 데이터셋 | uspto-grants-2010_11 |
| ORD ID | ord-d63f6ac0ae0d46888a58e608370ee763 |
| 출처 메모 | uspto-grants-2010_11 |