Sulfamide → 4-Ethanesulfonylpiperazine-1-sulfonamide

HRID 1175449노트

반응식

HRID 1175449 반응식
[CH2:1]([S:3]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)(=[O:5])=[O:4])[CH3:2].[S:12](N)([NH2:15])(=[O:14])=[O:13]>O1CCOCC1>[CH2:1]([S:3]([N:6]1[CH2:7][CH2:8][N:9]([S:12]([NH2:15])(=[O:14])=[O:13])[CH2:10][CH2:11]1)(=[O:5])=[O:4])[CH3:2]

참가 물질

4

반응물 2

HCID 82267SulfamideHCID 4152941-(Ethanesulfonyl)piperazine

생성물 1

HCID 536283734-Ethanesulfonylpiperazine-1-sulfonamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
100 °C

실험 절차

To a solution of 1-ethanesulfonylpiperazine (1.0 g) in dioxane (10 ml) was added sulfamide (0.51 g). The reaction was then heated at 100° C. for 24 h. The reaction was allowed to cool before being concentrated in vacuo. The residue was stirred in Et2O for 4 h and the mixture filtered to give the product as a white solid. Yield: 1.3 g.

후처리

  1. temperatureto cool
  2. concentrationbefore being concentrated in vacuo
  3. filtrationthe mixture filtered

출처 및 근거

ORD 기록
ord-1a2b9eeb94a54934a6adebcb257ee786
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07838675B2

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