Acetic Acid → Piperidine-4-sulfonamide

HRID 1175545노트

반응식

HRID 1175545 반응식
[NH2:1][S:2]([CH:5]1[CH2:10][CH2:9][N:8](C(OCC2C=CC=CC=2)=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].C(O)(=O)C>CO.[Pd]>[NH:8]1[CH2:9][CH2:10][CH:5]([S:2]([NH2:1])(=[O:4])=[O:3])[CH2:6][CH2:7]1

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 59353042Benzyl 4-sulfamoylpiperidine-1-carboxylate2회

생성물 1

HCID 18351283Piperidine-4-sulfonamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Benzyl 4-(aminosulfonyl)piperidine-1-carboxylate (the product from step i), 3.3 g) was dissolved in MeOH (20 ml). To this solution was added acetic acid (0.5 ml) and a catalytic amount of Pd/C. The reaction mixture was subjected to a pressure of 5 bar under an atmosphere of hydrogen gas for 18 h at RT. The reaction was filtered through celite and the filtrate was reduced in vacuo to give the subtitle compound as a white solid. Yield 1.7 g

후처리

  1. filtrationThe reaction was filtered through celite

출처 및 근거

ORD 기록
ord-4f27ff33da2b4b75b151e366676526f4
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07838675B2

반응 노트

불러오는 중…