3-Isopropoxybenzeneboronic acid → N-isobutyl-2-(3'-isopropoxybiphenyl-4-yl)-2-methylpropanamide

HRID 1175580

반응식

HRID 1175580 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:17])([CH3:16])[C:9]([NH:11][CH2:12][CH:13]([CH3:15])[CH3:14])=[O:10])=[CH:4][CH:3]=1.[CH:18]([O:21][C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][CH:27]=1)([CH3:20])[CH3:19]>>[CH2:12]([NH:11][C:9](=[O:10])[C:8]([C:5]1[CH:6]=[CH:7][C:2]([C:26]2[CH:25]=[CH:24][CH:23]=[C:22]([O:21][CH:18]([CH3:20])[CH3:19])[CH:27]=2)=[CH:3][CH:4]=1)([CH3:17])[CH3:16])[CH:13]([CH3:15])[CH3:14]

참가 물질

3

반응물 2

HCID 50839323-Isopropoxybenzeneboronic acidHCID 687750752-(4-Bromophenyl)-N-isobutyl-2-methylpropanamide

생성물 1

HCID 58789410N-isobutyl-2-(3'-isopropoxybiphenyl-4-yl)-2-methylpropanamide수율 60%

실험 절차

Prepared in a similar manner to Example 8 from 2-(4-Bromophenyl)-N-isobutyl-2-methylpropanamide (Example 1a) and 3-isopropoxyphenylboronic acid. Yield: 60%. 1H NMR (400 MHz, CDCl3): δ 0.8 (d, 6H), 1.35 (d, 6H), 1.65 (s, 6H), 1.67-1.70 (m,1H), 3 (m, 2H), 4.6 (m, 1H), 6.9 (dd, 1H), 7.1 (t, 1H), 7.15 (d, 1H), 7.35 (t, 1H), 7.45 (d, 2H), 7.6 (d, 2H). MS (M+H, 354).

출처 및 근거

ORD 기록
ord-0df89f3358214999a39794e03a8a52a8
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842324B2

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