3-(Methoxymethyl)benzeneboronic acid → 2-(3'-(Methoxymethyl)biphenyl-4-yl)-2-methylpropanoic acid

HRID 1175617

반응식

HRID 1175617 반응식
[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[C:6](B(O)O)[CH:7]=[CH:8][CH:9]=1.Br[C:14]1[CH:19]=[CH:18][C:17]([C:20]([CH3:25])([CH3:24])[C:21]([OH:23])=[O:22])=[CH:16][CH:15]=1>>[CH3:1][O:2][CH2:3][C:4]1[CH:5]=[C:6]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:25])([CH3:24])[C:21]([OH:23])=[O:22])=[CH:16][CH:15]=2)[CH:7]=[CH:8][CH:9]=1

참가 물질

3

반응물 2

HCID 38258553-(Methoxymethyl)benzeneboronic acidHCID 109336792-(4-Bromophenyl)-2-methylpropanoic acid

생성물 1

HCID 687743992-(3'-(Methoxymethyl)biphenyl-4-yl)-2-methylpropanoic acid수율 82%

실험 절차

Prepared in a similar manner to Example 1 starting from 3-(methoxymethyl)phenylboronic acid and 2-(4-bromophenyl)-2-methylpropanoic acid. Yield: 82%. 1H NMR (400 MHz, DMSO): δ 1.48 (s, 6H), 4.46 (s, 2H), 7.27-7.29 (d, 1H), 7.40-7.44 (m, 3H), 7.54-7.56 (d, 2H), 7.60-7.62 (d, 2H), 12.40 (s, 1H).

출처 및 근거

ORD 기록
ord-1a59ea9a507344848276791e938729e8
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842324B2

연결된 노트

불러오는 중…