3-{[(1S)-1-methylpropyl]oxy}-N-(1-methyl-1H-pyrazol-3-yl)-5-[(phenylmethyl)oxy]benzamide → HCID 59127175, 화합물

HRID 1175879노트

반응식

HRID 1175879 반응식
[CH3:1][C@H:2]([O:5][C:6]1[CH:7]=[C:8]([CH:18]=[C:19]([O:21]CC2C=CC=CC=2)[CH:20]=1)[C:9]([NH:11][C:12]1[CH:16]=[CH:15][N:14]([CH3:17])[N:13]=1)=[O:10])[CH2:3][CH3:4]>C1COCC1.C(O)C.[Pd]>[OH:21][C:19]1[CH:18]=[C:8]([CH:7]=[C:6]([O:5][C@@H:2]([CH3:1])[CH2:3][CH3:4])[CH:20]=1)[C:9]([NH:11][C:12]1[CH:16]=[CH:15][N:14]([CH3:17])[N:13]=1)=[O:10]

참가 물질

5

반응물 1

HCID 536296373-{[(1S)-1-methylpropyl]oxy}-N-(1-methyl-1H-pyrazol-3-yl)-5-[(phenylmethyl)oxy]benzamide

생성물 1

HCID 59127175HCID 59127175, 화합물수율 99.5%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 3-{[(1S)-1-methylpropyl]oxy}-N-(1-methyl-1H-pyrazol-3-yl)-5-[(phenylmethyl)oxy]benzamide (900 mg) in THF (5 mL) and ethanol (5 mL) containing 10% palladium on carbon was stirred under an atmosphere of hydrogen overnight. The palladium on carbon was removed by filtration and the filtrate evaporated under reduced pressure to give the required compound as a white solid (683 mg). 1H NMR δ (CDCl3): 0.95 (t, 3H), 1.27 (d, 3H), 1.54-1.80 (m, 2H), 3.79 (s, 3H), 4.31 (q, 1H), 6.57 (t, 1H), 6.81 (d, 1H), 6.96 (s, 1H), 6.98 (s, 1H), 7.30 (s, 1H), 7.57 (s, 1H), 8.84 (s, 1H); m/z 290 (M+H)+

후처리

  1. customThe palladium on carbon was removed by filtration
  2. customthe filtrate evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-9e137978bf1a4b6fb95647a05475c3e0
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842694B2

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