Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Bicarbonate → HCID 178478381, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 2-Chlorophenylboronic acid | HCID 2734322 | — |
| 반응물 | Potassium phenoxide | HCID 23670670 | — |
| 반응물 | HCID 178478383 | HCID 178478383 | — |
| 촉매 | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178478381 | HCID 178478381 | 63% |
반응 단계
To (2-Chloro-6-iodo-quinazolin-4-yl)-(5-cyclopropyl-2H-pyrazol-3-yl)-amine (100 mg, 0.243 mmol) and 2-chlorophenyl boronic acid (57 mg, 0.364 mmol) in DMSO (5 mL, purged with Ar) was added 1.5M potassium phenolate solution (648 μL, 0.97 mmol) and 1,1′bis(diphenylphosphino)ferrocene palladium chloride, complex with dichloromethane (27 mg) and the solution was heated to 60 C in a sealed tube. After 1 hr, solution was poured into sat. NaHCO3 resulting in a yellow solid that was colleted by filtration. Flash chromatography (1-4% methanol in dichloromethane) to give: 73 mg (63% yield). LCMS m/e: 396.2 (M+H), 394.2 (M-H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07842712B2 |
| 출처 데이터셋 | uspto-grants-2010_11 |
| ORD ID | ord-eba73d1f78184cff80cccd1cc6e7c417 |
| 출처 메모 | uspto-grants-2010_11 |