Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Duloxetine Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Duloxetine | HCID 60835 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | Duloxetine Hydrochloride | HCID 60834 | 94.64% |
반응 단계
To a solution of 1 g of duloxetine in 10 ml MEK was slowly added 0.32 ml of a 37 percent hydrochloric acid solution. The mixture was stirred until a solid formed. The resulting solid was filtered, and dried in a vacuum oven to give 0.50 g of (S)-(+)-duloxetine hydrochloride. (94.64% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07842717B2 |
| 출처 데이터셋 | uspto-grants-2010_11 |
| ORD ID | ord-573d9e7849e74a3b9b1d1608f68b2736 |
| 출처 메모 | uspto-grants-2010_11 |