Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromo-1-bromomethyl-3-nitrobenzene → Benzyl 3-(2-bromo-3-nitrobenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromo-1-bromomethyl-3-nitrobenzene | HCID 11066342 | — |
| 반응물 | Benzyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate | HCID 68499596 | — |
| 생성물 | Benzyl 3-(2-bromo-3-nitrobenzyloxy)-4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}piperidine-1-carboxylate | HCID 68502204 | — |
반응 단계
Analogously to Method D, 1.30 g of benzyl 3-hydroxy-4-{4-[3-(2-methoxybenzyloxy)propoxy]-phenyl}piperidine-1-carboxylate (Example 10f) and 1.0 g of 2-bromo-1-bromomethyl-3-nitrobenzene are reacted. The title compound is obtained as a yellowish oil. Rf=0.29 (1:1 EtOAc-heptane); Rt=6.12.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07842688B2 |
| 출처 데이터셋 | uspto-grants-2010_11 |
| ORD ID | ord-62597cd8fd424b31aa87ce922fb704b1 |
| 출처 메모 | uspto-grants-2010_11 |