Methanol → HCID 68502921, 화합물
반응식
[CH3:1][C:2]1[C:10]2[O:9][C:8]([C:11]([OH:13])=[O:12])=[CH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:14]O>OS(O)(=O)=O>[CH3:1][C:2]1[C:10]2[O:9][C:8]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
A solution of 4.32 g of 7-methylbenzofuran-2-carboxylic acid in 150 ml of methanol and 1 ml of conc. H2SO4 is stirred at reflux over 9 hours. The reaction mixture is cooled and concentrated by evaporation. The residue is dissolved in diethyl ether and washed with water, saturated aqueous sodium hydrogencarbonate solution and brine, dried over sodium sulphate and concentrated by evaporation. The crude title compound is obtained as a red-brown oil from the residue. Rf=0.32 (1:6 EtOAc-heptane); Rt=4.51.
후처리
- temperatureat reflux over 9 hours
- temperatureThe reaction mixture is cooled
- concentrationconcentrated by evaporation
- dissolutionThe residue is dissolved in diethyl ether
- washwashed with water, saturated aqueous sodium hydrogencarbonate solution and brine
- dry with materialdried over sodium sulphate
- concentrationconcentrated by evaporation
출처 및 근거
- ORD 기록
- ord-1457b75f028c47ce852ebfebff9cae80
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07842688B2
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