Methylamine → 4-(2-hydroxyphenyl)-N-methylbutyramide

HRID 1176398노트

반응식

HRID 1176398 반응식
[O:1]1[C:7](=[O:8])[CH2:6][CH2:5][CH2:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.[CH3:13][NH2:14]>C(O)(C)C>[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][CH2:6][C:7]([NH:14][CH3:13])=[O:8]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 109757954,5-Dihydrobenzo[b]oxepin-2(3H)-one

생성물 1

HCID 685011294-(2-hydroxyphenyl)-N-methylbutyramide

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A solution of 1.0 g of 4,5-dihydro-3H-benzo[b]oxepin-2-one and 40 ml of 10% methylamine in isopropanol is heated in an autoclave at 100° C. over 16 hours. The reaction mixture is cooled to room temperature and concentrated by evaporation. The title compound is obtained as white crystals from the residue by means of flash chromatography (SiO2 60F). Rf=0.20 (4:1 EtOAc-heptane); Rt=2.66.

후처리

  1. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-46c0c9a46292460a8488aa84ee483bde
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842688B2

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