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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1176436생성일: 2026년 10월 27일

1-(3-Bromopropoxy)-2-fluorobenzene → tert-Butyl 4-{4-[3-(2-fluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate

https://huagongshe.com/reaction/1176436

반응식

참여 물질

역할이름HCID투입량
반응물1-(3-Bromopropoxy)-2-fluorobenzeneHCID 7172293—
반응물(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylateHCID 21713087—
생성물tert-Butyl 4-{4-[3-(2-fluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylateHCID 68501698—

반응 단계

Analogously to Method I, 0.750 g of tert-butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 0.753 g of 1-(3-bromopropoxy)-2-fluorobenzene are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.53 (2:1 EtOAc-heptane); Rt=5.10.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07842688B2
출처 데이터셋uspto-grants-2010_11
ORD IDord-03d41e632d7348a4afd67409e4cbb298
출처 메모uspto-grants-2010_11