Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(3-Bromopropoxy)-4-fluorobenzene → Tert-butyl 4-{4-[3-(4-fluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(3-Bromopropoxy)-4-fluorobenzene | HCID 260004 | — |
| 반응물 | (3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate | HCID 21713087 | — |
| 생성물 | Tert-butyl 4-{4-[3-(4-fluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate | HCID 68501103 | — |
반응 단계
Analogously to Method I, 0.750 g of tert-butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate and 0.758 g of 1-(3-bromopropoxy)-4-fluorobenzene are reacted. The title compound is obtained as a slightly yellowish oil. Rf=0.13 (1:2 EtOAc-heptane); Rt=5.12.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07842688B2 |
| 출처 데이터셋 | uspto-grants-2010_11 |
| ORD ID | ord-608a5ef83ea44fd2978c81811e5fad92 |
| 출처 메모 | uspto-grants-2010_11 |