Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → tert-Butyl [3-(2,5-difluorophenoxy)propyl]carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 반응물 | 2,5-Difluorophenol | HCID 94952 | — |
| 반응물 | tert-butyl N-(3-hydroxypropyl)carbamate | HCID 3838134 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | tert-Butyl [3-(2,5-difluorophenoxy)propyl]carbamate | HCID 86610028 | — |
반응 단계
The solution of 2.50 g of 2,5-difluorophenol, 3-(Boc-amino)-1-propanol, 7.26 g of triphenylphosphine and tetrahydrofuran (30 ml) is cooled to 0° C. and admixed dropwise with 5.65 ml of diisopropyl azodicarboxylate. The reaction mixture is stirred at room temperature for a further 2 hours and subsequently concentrated by evaporation. The title compound is obtained as a yellowish solid from the residue by means of flash chromatography (SiO2 60F). Rf=0.34 (1:2 EtOAc-heptane); Rt=4.69.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07842688B2 |
| 출처 데이터셋 | uspto-grants-2010_11 |
| ORD ID | ord-9126ced901db45dc82bef3e4a226095b |
| 출처 메모 | uspto-grants-2010_11 |