4-(2-Chloro-4-methanesulfonyl-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid methyl ester → 4-(2-Chloro-4-methanesulfonyl-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid
반응식
CS(C1C=CC(OC2C3CC(C)(C)OC=3C=C(C(O)=O)C=2)=CC=1)(=O)=O.C[O:27][C:28]([C:30]1[CH:40]=[C:39]([O:41][C:42]2[CH:47]=[CH:46][C:45]([S:48]([CH3:51])(=[O:50])=[O:49])=[CH:44][C:43]=2[Cl:52])[C:33]2[CH2:34][C:35]([CH3:38])([CH3:37])[O:36][C:32]=2[CH:31]=1)=[O:29]>>[Cl:52][C:43]1[CH:44]=[C:45]([S:48]([CH3:51])(=[O:49])=[O:50])[CH:46]=[CH:47][C:42]=1[O:41][C:39]1[C:33]2[CH2:34][C:35]([CH3:38])([CH3:37])[O:36][C:32]=2[CH:31]=[C:30]([C:28]([OH:29])=[O:27])[CH:40]=1참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was prepared in a similar manner as described for Intermediate 15a, from 4-(2-chloro-4-methanesulfonyl-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid methyl ester (119a). 1H NMR (400 MHz, CDCl3) δ 8.08 (d, J=2.27 Hz, 1 H) 7.78 (dd, J=8.59, 2.27 Hz, 1 H) 7.34 (d, J=1.26 Hz, 1 H) 7.23 (d, J=1.26 Hz, 1 H) 7.00 (d, J=8.59 Hz, 1 H) 3.11 (s, 3 H) 2.95 (s, 2 H) 1.52 (s, 6 H); LCMS for C18H17ClO6S m/z 397.00 (M+H)+.