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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1177636생성일: 2026년 10월 27일

Ethyl 4-bromobutyrate → 1-(3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-pyrrolidinone

https://huagongshe.com/reaction/1177636

반응식

참여 물질

역할이름HCID투입량
반응물Ethyl 4-bromobutyrateHCID 76300—
반응물3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzenamineHCID 57403052—
생성물1-(3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-pyrrolidinoneHCID 59174902—

반응 단계

3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzenamine (110 mg, 0.304 mmol) was dissolved in ethyl 4-bromobutanoate (59 mg, 0.304 mmol) before it was placed in the microwave for 60 min at 140° C. The title compound was obtained after flash chromatography. MS (ESI) m/z: Calculated: 429.1; Observed: 430.1 (M++1).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07842685B2
출처 데이터셋uspto-grants-2010_11
ORD IDord-42bc22b3b49a4a5fa5aa4de3a2b1a162
출처 메모uspto-grants-2010_11