참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | Methyl 4-fluorobenzoate | HCID 67878 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Methyl 4-(4-methylpiperazin-1-yl)benzoate | HCID 1472668 | 165.4% |
반응 단계
A mixture of 1-methyl-piperazine (1.3 g, 1.2 mmol) and 4-fluoro benzoic acid methyl ester (500 mg, 0.32 mmol) was stirred with heating at 120° C. for 20 hrs. Cold water then added, filtered the solid precipitated to afford 124 mg (16.4% yield) of 4-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester. 1H NMR (CDCl3): δ 8.0 (d, 2H), 6.9 (d, 2H), 3.9 (s, 3H), 3.4 (t, 4H), 2.6 (t, 4H), 2.4 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07842696B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_11 |
|---|
| ORD ID | ord-6763c9f137b84040ac0a714402222c3c |
|---|
| 출처 메모 | uspto-grants-2010_11 |
|---|
