Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-Ethynylbenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Methyl 4-ethynylbenzoate | HCID 640163 | — |
| 용매 | Methanol--water (1/1) | HCID 22242641 | — |
| 생성물 | 4-Ethynylbenzoic acid | HCID 589706 | 81.9% |
반응 단계
LiOH (95.97 mg, 2.2 mmol) was added to a stirred solution of 4-ethynyl-benzoic acid methyl ester (305 mg, 1.9 mmol) in MeOH:H2O (1:1, 6 mL), and the resulting mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated under reduced pressure to get the residue. Cold water was then added, acidified it with conc.HCl and extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford 226 mg (81.9% yield) of 4-ethynyl-benzoic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07842696B2 |
| 출처 데이터셋 | uspto-grants-2010_11 |
| ORD ID | ord-7dcc3f786f9d404a9c76c6f619b43ad7 |
| 출처 메모 | uspto-grants-2010_11 |