3,4,5-Trimethoxyaniline → 2,3,4-Trimethoxycyclohexylamine

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:7]=[C:8]([O:12][CH3:13])[C:9]=1[O:10][CH3:11])N.C(C1C=C(C=C(C(O)=O)C=1)[NH2:20])(O)=O>>[CH3:1][O:2][CH:3]1[CH:9]([O:10][CH3:11])[CH:8]([O:12][CH3:13])[CH2:7][CH2:5][CH:4]1[NH2:20]

참가 물질

반응물 2

HCID 322853,4,5-Trimethoxyaniline

HCID 668335-Aminoisophthalic acid

생성물 1

HCID 225599332,3,4-Trimethoxycyclohexylamine

실험 절차

3,4,5-trimethoxyaniline was hydrogenated via the procedure given for 3,5-dicarboxy-aniline to provide 2,3,4-trimethoxycyclohexylamine which was coupled to the C-terminal valine in the standard way.

출처 및 근거

ORD 기록: ord-9ddddc4f8b124809a4e0345279e96eed
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07276484B2

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