4-(5-chloro-[1H]-indol-3-yl)-piperidine → HCID 131724873, 화합물

반응식

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.Cl[CH2:18][CH2:19][CH2:20][C:21]([N:23]1[C:32]2[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:26][CH2:25][CH2:24]1)=[O:22]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH2:18][CH2:19][CH2:20][C:21]([N:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH2:26][CH2:25][CH2:24]2)=[O:22])[CH2:13][CH2:12]1

참가 물질

반응물 2

HCID 128313754-(5-chloro-[1H]-indol-3-yl)-piperidine

HCID 16638840HCID 16638840, 화합물

생성물 1

HCID 131724873HCID 131724873, 화합물

실험 절차

from 5-chloro-3-(piperidin-4-yl)-1H-indole and 4-chloro-1-(3,4-dihydro-2H-quinolin-1-yl)butan-1-one. Mp 158-162° C. 1H NMR (DMSO-d6): 1.85-1.95 (m, 2H); 1.95-2.20 (m, 6H); 2.60-2.75 (m, 4H); 2.95-3.15 (m, 5H); 3.55 (d, 2H); 3.70 (t, 2H); 7.05-7.25 (m, 6H); 7.40 (d, 1H); 7.75 (s, 1H); 10.45 (broad s, 1H); 11.15 (s, 1H). MS m/z: 436 (MH+), 303.

출처 및 근거

ORD 기록: ord-6e2f4f7e09a74a228223337b41b4a293
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07276508B2

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