Benzaldehyde → HCID 58696280, 화합물

HRID 1178321노트

반응식

HRID 1178321 반응식
C(N(CC)CC)C.[CH:8](=O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.Cl.[NH2:17][CH:18]([C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[C:26]([Cl:31])[CH:25]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20]>C(#N)C>[CH2:22]([O:21][C:19](=[O:20])[CH:18]([N:17]=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[C:26]([Cl:31])[CH:25]=1)[CH3:23]

참가 물질

5

반응물 3

HCID 240BenzaldehydeHCID 8471TriethylamineHCID 6949597672954-97-3

생성물 1

HCID 58696280HCID 58696280, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Triethylamine (170 mL) and benzaldehyde (130 mL) were added to a suspension of ethyl amino-(3,4-dichlorophenyl)-acetate hydrochloride (350 g) in acetonitrile (1.5 L), followed by stirring at room temperature overnight. The insoluble matter was removed through Celite, followed by washing with ethyl acetate. The filtrate was subjected to partitioning with water and then extraction with ethyl acetate. The thus-obtained organic layer was washed with saturated brine, and then dried over sodium sulfate anhydrate. The solvent was removed under reduced pressure, to thereby give the title compound (425 g). The title compound was used in the next step without further purification.

후처리

  1. customThe insoluble matter was removed through Celite
  2. washby washing with ethyl acetate
  3. customto partitioning with water
  4. extractionextraction with ethyl acetate
  5. washThe thus-obtained organic layer was washed with saturated brine
  6. dry with materialdried over sodium sulfate anhydrate
  7. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-05cd4704ccac4b3185bf5dea055323e5
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07276511B2

반응 노트

불러오는 중…