(3-Methoxy-2-propylbenzyl)-dimethylamine → 3-Dimethylaminomethyl-2-propylphenol hydrobromide

HRID 1178523노트

반응식

HRID 1178523 반응식
C[O:2][C:3]1[C:4]([CH2:13][CH2:14][CH3:15])=[C:5]([CH:10]=[CH:11][CH:12]=1)[CH2:6][N:7]([CH3:9])[CH3:8].[BrH:16].C(O)(=O)C>>[BrH:16].[CH3:9][N:7]([CH2:6][C:5]1[C:4]([CH2:13][CH2:14][CH3:15])=[C:3]([OH:2])[CH:12]=[CH:11][CH:10]=1)[CH3:8]

참가 물질

3

반응물 2

HCID 13780988(3-Methoxy-2-propylbenzyl)-dimethylamineHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

생성물 1

HCID 137809963-Dimethylaminomethyl-2-propylphenol hydrobromide수율 79%

실험 절차

(3-Methoxy-2-propylbenzyl)-dimethylamine (1.51 g, 7.28 mmol) was suspended in 30% hydrogen bromide/acetic acid (10 mL) and heated to reflux with stirring for 20 h. The cooled reaction mixture was triturated and decanted with successive portions of diethyl ether (4×), then triturated with diethyl ether overnight. The solid was collected by filtration, washed with ether and dried to give 3-dimethylaminomethyl-2-propylphenol hydrobromide (1.58 g, 79%) as a tan solid.

후처리

  1. temperatureheated
  2. temperatureto reflux
  3. customThe cooled reaction mixture
  4. customwas triturated
  5. customdecanted with successive portions of diethyl ether (4×)
  6. customtriturated with diethyl ether overnight
  7. filtrationThe solid was collected by filtration
  8. washwashed with ether
  9. customdried

출처 및 근거

ORD 기록
ord-74da8df2f07e4738a44d503a6889cf73
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07276528B2

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