참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methyl Acrylate | HCID 7294 | — |
| 반응물 | 4-Aminophenethyl alcohol | HCID 66904 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Methyl 2-chloro-3-[4-(2-hydroxyethyl)phenyl]propanoate | HCID 86600802 | — |
반응 단계
2-(4-Aminophenyl)ethanol (11 g, 81 mmol) and 32 ml conc HCl was dissolved in acetone and cooled to 0° C. Sodium nitrite (5.6 g, 81 mmol) in 20 ml water was added dropwise. The temperature was kept under 0° C. After one hour, methyl acrylate (70 g, 808 mmol) and CuI (1.6 g, 8 mmol) were added (<0° C.). The reaction mixture was stirred at room temperature overnight.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07276539B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_10 |
|---|
| ORD ID | ord-1c9e5fe183944f61a4850dedfa5753dd |
|---|
| 출처 메모 | uspto-grants-2007_10 |
|---|
