Toluene → Ethyl(6-methoxy-1-benzofuran-3-yl)acetate

HRID 1178796노트

반응식

HRID 1178796 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]2[C:7](=O)[CH2:8][O:9][C:5]=2[CH:4]=1.[C:13]([CH:16]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([OH:15])=[O:14].[C:36]1(C)C=CC=C[CH:37]=1>>[CH2:36]([O:15][C:13](=[O:14])[CH2:16][C:7]1[C:6]2[CH:11]=[CH:12][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[O:9][CH:8]=1)[CH3:37]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 5853686-Methoxy-2,3-dihydro-1-benzofuran-3-oneHCID 10870911Carboxymethylene triphenylphosphorane

생성물 1

HCID 23614459Ethyl(6-methoxy-1-benzofuran-3-yl)acetate

실험 절차

A mixture of 6-methoxy-benzofuran-3 (2H)-one (1.64 g, 10 mmol) and (carboxymethylene)triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. Afterwards, reaction mixture was concentrated and loaded over a silica-gel column. The column was eluted with hexane (500 ml) and then with 25% ethyl acetate. The product, ethyl(6-methoxy-1-benzofuran-3-yl)acetate, was obtained as a white oil. Yield: 1.8 g (76%); (M+H): 235.

후처리

  1. customAfterwards, reaction mixture
  2. concentrationwas concentrated
  3. washThe column was eluted with hexane (500 ml)

출처 및 근거

ORD 기록
ord-db6b5b909acf48d6b43be2069e284434
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07276603B2

반응 노트

불러오는 중…