Toluene → Ethyl(7-methoxy-1-benzofuran-3-yl)acetate

HRID 1178810

반응식

HRID 1178810 반응식
[CH3:1][O:2][C:3]1[C:11]2[O:10][CH2:9][C:8](=O)[C:7]=2[CH:6]=[CH:5][CH:4]=1.[C:13]([CH:16]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([OH:15])=[O:14].[C:36]1(C)C=CC=C[CH:37]=1>>[CH2:36]([O:15][C:13](=[O:14])[CH2:16][C:8]1[C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:11]=2[O:10][CH:9]=1)[CH3:37]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 28181127-Methoxybenzofuran-3(2H)-oneHCID 10870911Carboxymethylene triphenylphosphorane

생성물 1

HCID 22734085Ethyl(7-methoxy-1-benzofuran-3-yl)acetate

실험 절차

A mixture of 7-methoxy-benzofuran-3 (2H)-one (1.64 g, 10 mmol) and (carboxymethylene)triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. At the end, reaction mixture was concentrated and loaded over a silica-gel column. The column was eluted with hexane (500 ml) and then with 25% ethyl acetate. The product, ethyl(7-methoxy-1-benzofuran-3-yl)acetate, was obtained as a white oil. Yield: 1.9 g (81%); (M+H): 235.

후처리

  1. customAt the end, reaction mixture
  2. concentrationwas concentrated
  3. washThe column was eluted with hexane (500 ml)

출처 및 근거

ORD 기록
ord-4feca9c39d1f4bb1a5bb3db40035aaad
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07276603B2

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