1-(Triphenylphosphoranylidene)acetone → 1-(7-Methoxy-1-benzofuran-3-yl)propan-2-one

HRID 1178826

반응식

HRID 1178826 반응식
[CH3:1][O:2][C:3]1[C:11]2[O:10][CH2:9][C:8](=O)[C:7]=2[CH:6]=[CH:5][CH:4]=1.C1(P(C2C=CC=CC=2)(C2C=CC=CC=2)=[CH:20][C:21](=[O:23])[CH3:22])C=CC=CC=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:11]2[O:10][CH:9]=[C:8]([CH2:20][C:21]([CH3:22])=[O:23])[C:7]=2[CH:6]=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 150381-(Triphenylphosphoranylidene)acetoneHCID 28181127-Methoxybenzofuran-3(2H)-one

생성물 1

HCID 236144341-(7-Methoxy-1-benzofuran-3-yl)propan-2-one

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 7-methoxy-benzofuran-3 (2H)-one (1.64 g, 10 mmol) and 1-triphenylphosphoranylidene-2-propanone (4.77 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. At the end, reaction mixture was concentrated and loaded over a silica-gel column. The column was eluted with hexane (500 ml) and later with 25% ethyl acetate. The product, 1-(7-methoxy-1-benzofuran-3-yl)acetone, was obtained as a red oil. Yield: 1.4 g (68%); (M+H): 205.

후처리

  1. customAt the end, reaction mixture
  2. concentrationwas concentrated
  3. washThe column was eluted with hexane (500 ml) and later with 25% ethyl acetate

출처 및 근거

ORD 기록
ord-62faf2259e2f4ddfb2d0944fa65330d9
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07276603B2

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