참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | trans-1,2-Indandiol | HCID 247603 | — |
| 생성물 | (1R,2S)-(+)-cis-1-Amino-2-indanol | HCID 2725045 | 63% |
반응 단계
Trans-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C., and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol (1.02 g, 63% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05723615 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-0d0c32a5746a47be8dab7284d54a01f0 |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
