Methanol → Methyl 2-amino-4,4-dimethylpentanoate

HRID 1179149노트

반응식

HRID 1179149 반응식
[NH2:1][CH:2]([CH2:6][C:7]([CH3:10])([CH3:9])[CH3:8])[C:3]([OH:5])=[O:4].S(Cl)(Cl)=O.[CH3:15]O>>[CH3:15][O:4][C:3](=[O:5])[CH:2]([NH2:1])[CH2:6][C:7]([CH3:10])([CH3:9])[CH3:8]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 3516272-Amino-3-tert-butylpropionic acid

생성물 1

HCID 23000049Methyl 2-amino-4,4-dimethylpentanoate

실험 절차

2-Amino-4,4-dimethyl-pentanoic acid (1.00 g, 6.84 mmol) was suspended in 50 mL of methanol and cooled in an ice bath. Thionyl chloride (1.82 g, 15.0 mmol) was added dropwise, at which time all the acid went into solution. The reaction was then removed from the ice bath and heated to reflux for 3.5 h. The reaction mixture was concentrated in vacuo and the resulting solid (1.10 g) was used in the next step without further purification. MS, m/z 159.9=M+1

후처리

  1. temperaturecooled in an ice bath
  2. customThe reaction was then removed from the ice bath
  3. temperatureheated
  4. temperatureto reflux for 3.5 h
  5. concentrationThe reaction mixture was concentrated in vacuo
  6. customthe resulting solid (1.10 g) was used in the next step without further purification

출처 및 근거

ORD 기록
ord-a4d5bc2b52a446ce8cac5e039e167f27
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279472B2

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