Sodium Methoxide → Methyl 4-Hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

HRID 1179324노트

반응식

HRID 1179324 반응식
[CH3:1][O:2][C:3](=[O:18])[CH2:4][C:5]([NH:7][C:8]1[C:9]([C:14]([O:16]C)=O)=[N:10][CH:11]=[CH:12][CH:13]=1)=[O:6].C[O-].[Na+]>>[OH:16][C:14]1[C:9]2[C:8](=[CH:13][CH:12]=[CH:11][N:10]=2)[NH:7][C:5](=[O:6])[C:4]=1[C:3]([O:2][CH3:1])=[O:18]

참가 물질

3

반응물 2

HCID 10942334Sodium Methoxide2회HCID 42637833Methyl 3-[(3-methoxy-3-oxopropanoyl)amino]pyridine-2-carboxylate

생성물 1

HCID 54729994Methyl 4-Hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

실험 절차

To a solution of methyl 3-[(3-methoxy-3-oxopropanoyl)amino]pyridine-2-carboxylate (7.3 g, 29.9 mmol, prepared as described in example 1) in anhydrous TBF (100 mL) was added solid sodium methoxide (3.9 g, 72.4 mmol) at 0° C. Immediately following the addition of the sodium methoxide, solids crashed out of the solution. The ice bath was then removed and the suspension was stirred for an additional 0.5 hours. The suspension was then filtered through a medium porosity filtration funnel to afford yellow solids.

후처리

  1. customThe ice bath was then removed
  2. filtrationThe suspension was then filtered through a medium porosity filtration funnel
  3. customto afford yellow solids

출처 및 근거

ORD 기록
ord-f10dd82cdede403fb719c0f1b365ec62
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279487B2

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