2-Aminobenzimidazole → N1-(1H-benzo[d]imidazol-2-yl)propane-1,3-diamine

반응식

[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[NH:4][C:5]([NH:7][CH2:8][CH2:9][CH2:10][NH:11]C(=O)[O-])=S.NC1NC2C=CC=CC=2N=1>>[NH:4]1[C:3]2[CH:15]=[CH:16][CH:17]=[CH:18][C:2]=2[N:1]=[C:5]1[NH:7][CH2:8][CH2:9][CH2:10][NH2:11]

참가 물질

반응물 2

HCID 136242-Aminobenzimidazole

HCID 86591654HCID 86591654, 화합물

생성물 1

HCID 11593576N1-(1H-benzo[d]imidazol-2-yl)propane-1,3-diamine

실험 절차

3-{[(2-aminoanilino)carbothioyl]amino}propylcarbamate (ESI-MS; [M+H+]: 325.15), which was then converted with HgO/cat. S into the corresponding aminobenzimidazole (6.4 g; ESI-MS; [M+H+]: 291.15). After removal of the Boc group using TFA, the crude product obtained was boiled in CH3OH with addition of active carbon, filtered, evaporated and crystallized from CH3OH/methyl t-butyl ether; 6 g of beige solid; ESI-MS; [M+H+]: 191.1.

후처리

customAfter removal of the Boc group

출처 및 근거

ORD 기록: ord-cd404ac8509147f1a400930802b4ae79
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07279468B2

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