Water → 4-[4-(Hydroxymethyl)piperidin-1-yl]benzaldehyde
반응식
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[OH:10][CH2:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[OH:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:2]2[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=2)[CH2:14][CH2:13]1참가 물질
6
반응 조건
- 온도
- 100 °C
실험 절차
A suspension of 4-fluorobenzaldehyde (4.3 mL), 4-hydroxymethylpiperidine (4.8 g), and cesium carbonate (26 g) in DMF (80 mL) was heated to 100° C. for 24 h and cooled to room temperature. Water (400 mL) was added, and the resulting precipitate was collected by filtration to give the title compound as a tan amorphous powder (4.1 g).
후처리
- temperaturecooled to room temperature
- filtrationthe resulting precipitate was collected by filtration
출처 및 근거
- ORD 기록
- ord-eece5a71b93c41c7b2457cced25857be
- 출처 데이터셋
- uspto-grants-2007_10
- 특허 번호
- US07279491B2
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