Ethylamine → 8-(1-Azabicyclo[2.2.2]oct-3-yl)-2-methyl-3,6-dihydroimidazo[4,5-e]indole

HRID 1179430노트

반응식

HRID 1179430 반응식
[CH2:1]([NH2:3])[CH3:2].[N:4]12[CH2:11][CH2:10][CH:7]([CH2:8][CH2:9]1)[CH:6]([C:12]1[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([NH2:21])[CH:19]=3)[NH:14][CH:13]=1)[CH2:5]2>CN(C)C=O.O=[Mn]=O>[N:4]12[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11]1)[CH:6]([C:12]1[C:20]3[C:15](=[CH:16][CH:17]=[C:18]4[NH:21][C:1]([CH3:2])=[N:3][C:19]4=3)[NH:14][CH:13]=1)[CH2:5]2

참가 물질

5

반응물 2

HCID 6341EthylamineHCID 98162073-(1-azabicyclo[2.2.2]oct-3-yl)-1H-indol-5-ylamine

생성물 1

HCID 114488658-(1-Azabicyclo[2.2.2]oct-3-yl)-2-methyl-3,6-dihydroimidazo[4,5-e]indole

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6228Dimethylformamide용매

실험 절차

2 mmol of ethylamine and 10 mmol of MnO2 are added to a solution of 1 mmol of 3-(1-azabicyclo[2.2.2]oct-3-yl)-1H-indol-5-ylamine in 20 ml of dimethylformamide (DMF), and the mixture is stirred at room temperature for 12 hours. The suspension is filtered through Celite and washed with DMF. After the solvent has been distilled, the mixture is subjected to conventional work-up, giving 8-(1-azabicyclo[2.2.2]oct-3-yl)-2-methyl-3,6-dihydroimidazo[4,5-e]indole; ESI 281.

후처리

  1. filtrationThe suspension is filtered through Celite
  2. washwashed with DMF
  3. distillationAfter the solvent has been distilled

출처 및 근거

ORD 기록
ord-391542ffb6cf467dadec0eb768da4dd3
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279496B2

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