1,1'-Carbonyldiimidazole → (S)-hexahydro-3H-pyrrolo[1,2-c]imidazol-3-one

HRID 1179644노트

반응식

HRID 1179644 반응식
[NH2:1][CH2:2][C@@H:3]1[CH2:7][CH2:6][CH2:5][NH:4]1.[C:8](N1C=CN=C1)(N1C=CN=C1)=[O:9]>C(Cl)Cl>[CH2:2]1[NH:1][C:8](=[O:9])[N:4]2[CH2:5][CH2:6][CH2:7][C@@H:3]12

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 2734054(S)-(+)-2-(Aminomethyl)pyrrolidine

생성물 1

HCID 14358392(S)-hexahydro-3H-pyrrolo[1,2-c]imidazol-3-one수율 50%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(S)-2-(Aminomethyl)pyrrolidine (250 mg) and carbonyldiimidazole (400 mg, 1.0 equiv.) were dissolved in DCM (50 mL). The resulting mixture was stirred at room temperature for 18 hours, then concentrated under vacuum. The residue was purified by flash column chromatography (SPE cartridge, SiO2), using DCM-methanol (95:5) as eluent to afford the title compound as colourless solid (150 mg, 50% yield).

후처리

  1. concentrationconcentrated under vacuum
  2. customThe residue was purified by flash column chromatography (SPE cartridge, SiO2)

출처 및 근거

ORD 기록
ord-92e890a2771741618196c33f9450711e
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279481B2

반응 노트

불러오는 중…