참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyridinium chloride | HCID 10176127 | — |
| 반응물 | Pyridine, 2-[(6-methoxy-3-pyridinyl)oxy]-5-(trifluoromethyl)- | HCID 22047745 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2(1H)-Pyridinone, 5-[[5-(trifluoromethyl)-2-pyridinyl]oxy]- | HCID 178516274 | 68% |
반응 단계
A mixture of 2-methoxy-5-(5-trifluoromethyl-pyridin-2-yloxy)-pyridine (0.28 g, 1.04 mmol) and pyridine hydrochloride (1.00 g, 8.65 mmol) was heated in a kugelrohr oven at 200° C. for 10 minutes. After cooling to room temperature, the reaction mixture is dissolved in dichloromethane and extracted with water, dried over sodium sulphate, filtered and evaporated in vacuo, yielding the title compound (180 mg, 68% yield) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07279470B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_10 |
|---|
| ORD ID | ord-a907f0d6dfaa454f9e2141c5604780d4 |
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| 출처 메모 | uspto-grants-2007_10 |
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