4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol → 4-Benzyl-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

HRID 1179759

반응식

HRID 1179759 반응식
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[N:7][CH:8]=1.[I-].C[N+]1C=CN([C:26]([N:28]2[CH2:33][CH2:32][CH:31]([CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH2:30][CH2:29]2)=[O:27])C=1>>[F:18][C:2]([F:1])([F:17])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:11]=[CH:12][C:13]([O:16][C:26]([N:28]3[CH2:29][CH2:30][CH:31]([CH2:34][C:35]4[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=4)[CH2:32][CH2:33]3)=[O:27])=[CH:14][CH:15]=2)=[N:7][CH:8]=1

참가 물질

3

반응물 2

HCID 1552414-(5-Trifluoromethyl-pyridin-2-yloxy)-phenolHCID 865891901-methyl-3-(4-benzyl-piperidine-1-carbonyl)-3H-imidazol-1-ium iodide

생성물 1

HCID 236356364-Benzyl-piperidine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

실험 절차

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenol and 1-methyl-3-(4-benzyl-piperidine-1-carbonyl)-3H-imidazol-1-ium iodide. The crude product was purified by flash chromatography using a Quad flash 25 (ethyl acetate/heptane (1:6), (72%, white crystals). HPLC-MS m/z=457.2 (M+1), Rt: 6.0 min.

후처리

  1. customThe crude product was purified by flash chromatography

출처 및 근거

ORD 기록
ord-43f5bab7ea7d40b1a2f908c3cb282673
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279470B2

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