Ethamivan → Methyl-phenyl-carbamic Acid 4-diethylcarbamoyl-2-methoxy-phenyl Ester

HRID 1179810

반응식

[CH2:1]([N:3]([CH2:15][CH3:16])[C:4](=[O:14])[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([O:12][CH3:13])[CH:6]=1)[CH3:2].[CH3:17][N:18]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:19](Cl)=[O:20]>>[CH2:15]([N:3]([CH2:1][CH3:2])[C:4]([C:5]1[CH:10]=[CH:9][C:8]([O:11][C:19](=[O:20])[N:18]([CH3:17])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:7]([O:12][CH3:13])[CH:6]=1)=[O:14])[CH3:16]

참가 물질

반응물 2

HCID 9363Ethamivan

HCID 77969Carbamic chloride, N-methyl-N-phenyl-

생성물 1

HCID 69519834Methyl-phenyl-carbamic Acid 4-diethylcarbamoyl-2-methoxy-phenyl Ester

실험 절차

The title product was prepared from N,N-diethyl-4-hydroxy-3-methoxy-benzamide and N-methyl-N-phenylcarbamoyl chloride. The crude product was subjected to preparative HPLC (58%, colorless oil). HPLC-MS: m/z=357.1 (M+1); Rt: 3.64 min.

출처 및 근거

ORD 기록: ord-b926100beef34922845287d820e3c1cd
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07279470B2

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